| 1. Round | 23/07/2021 | Club Necaxa [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 3. Round | 06/08/2021 | Club Necaxa [U18] | - | Cruz Azul [U18] | 5:0 | ||||
| 4. Round | 12/08/2021 | Atlético San Luis [U18] | - | Club Necaxa [U18] | 3:3 |  |
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| 6. Round | 22/08/2021 | Club Necaxa [U18] | - | FC Juárez [U18] | 3:2 |  |
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| 8. Round | 12/09/2021 | Gallos Blancos [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U18] | - | Atlas Guadalajara [U18] | 1:0 | ||||
| 10. Round | 23/09/2021 | CF Pachuca [U18] | - | Club Necaxa [U18] | 5:1 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Round | 03/10/2021 | UANL Tigres [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 13. Round | 15/10/2021 | Club Necaxa [U18] | - | Puebla FC [U18] | 4:3 | ||||
| 15. Round | 23/10/2021 | CF Monterrey [U18] | - | Club Necaxa [U18] | 1:3 | ||||
| 16. Round | 29/10/2021 | Club Necaxa [U18] | - | Mazatlán FC [U18] | 3:0 |
Mexico