| 2. Round | 13/08/2022 | FC Schalke 04 | - | Bor. Mönchengladbach | 2:2 | ||||
| 4. Round | 27/08/2022 | FC Schalke 04 | - | 1. FC Union Berlin | 1:6 | ||||
| 5. Round | 03/09/2022 | VfB Stuttgart | - | FC Schalke 04 | 1:1 | ||||
| 9. Round | 08/10/2022 | Bayer Leverkusen | - | FC Schalke 04 | 4:0 | ||||
| 10. Round | 14/10/2022 | FC Schalke 04 | - | 1899 Hoffenheim | 0:3 | ||||
| 11. Round | 23/10/2022 | Hertha BSC | - | FC Schalke 04 | 2:1 |  |
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| 12. Round | 30/10/2022 | FC Schalke 04 | - | SC Freiburg | 0:2 | ||||
| 13. Round | 05/11/2022 | Werder Bremen | - | FC Schalke 04 | 2:1 | ||||
| 14. Round | 09/11/2022 | FC Schalke 04 | - | 1. FSV Mainz 05 | 1:0 |  |
France