| 1. Round | 23/08/2021 | Apollon Limassol | - | Ethnikos Achna | 4:2 | ||||
| 2. Round | 11/09/2021 | Ethnikos Achna | - | PAEEK | 1:3 | ||||
| 3. Round | 20/09/2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 |  |
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| 4. Round | 24/09/2021 | Doxa Katokopias | - | Ethnikos Achna | 0:0 | ||||
| 5. Round | 02/10/2021 | Ethnikos Achna | - | Aris Limassol | 0:3 |  |
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| 6. Round | 18/10/2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 7. Round | 23/10/2021 | Ethnikos Achna | - | AEL Limassol | 2:2 | |
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| 8. Round | 31/10/2021 | AEK Larnaca | - | Ethnikos Achna | 1:0 | ||||
| 9. Round | 07/11/2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | ||||
| 10. Round | 20/11/2021 | Paphos FC | - | Ethnikos Achna | 3:0 | ||||
| 11. Round | 26/11/2021 | Ethnikos Achna | - | Olympiakos Nikosia | 1:0 | ||||
| 12. Round | 06/12/2021 | Ethnikos Achna | - | Apollon Limassol | 0:1 | |
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| 13. Round | 11/12/2021 | PAEEK | - | Ethnikos Achna | 0:2 | |
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| 15. Round | 03/01/2022 | Ethnikos Achna | - | Doxa Katokopias | 0:1 |
France