| 9. Round | 21/07/2022 | Rosario Central | - | Newell's Old Boys | 1:0 |  |
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| 10. Round | 27/07/2022 | Arsenal de Sarandí | - | Rosario Central | 0:3 | ||||
| 13. Round | 13/08/2022 | Rosario Central | - | Barracas Central | 3:1 | ||||
| 14. Round | 18/08/2022 | Boca Juniors | - | Rosario Central | 0:0 | ||||
| 15. Round | 22/08/2022 | Rosario Central | - | Banfield | 0:1 | ||||
| 16. Round | 27/08/2022 | San Lorenzo | - | Rosario Central | 1:1 | |
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| 17. Round | 03/09/2022 | Rosario Central | - | Talleres de Córdoba | 1:0 | ||||
| 18. Round | 09/09/2022 | Argentinos Juniors | - | Rosario Central | 2:1 | ||||
| 19. Round | 15/09/2022 | Rosario Central | - | Estudiantes | 1:1 | ||||
| 20. Round | 20/09/2022 | Patronato de Paraná | - | Rosario Central | 0:0 | |
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| 21. Round | 25/09/2022 | Rosario Central | - | Platense | 1:1 | ||||
| 22. Round | 01/10/2022 | Racing Club | - | Rosario Central | 4:3 | ||||
| 23. Round | 04/10/2022 | Rosario Central | - | Unión de Santa Fe | 1:1 | ||||
| 24. Round | 10/10/2022 | Rosario Central | - | Defensa y Justicia | 0:0 | ||||
| 25. Round | 14/10/2022 | Atlético Tucumán | - | Rosario Central | 1:1 | |
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| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 | ||||
| 27. Round | 24/10/2022 | Rosario Central | - | Colón de Santa Fe | 1:1 |
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Italy