| 1. Round | 12/02/2022 | Deportivo Madryn | - | Agropecuario Argentino | 1:0 | ||||
| 2. Round | 19/02/2022 | Tristan Suárez | - | Deportivo Madryn | 1:1 | ||||
| 3. Round | 26/02/2022 | Deportivo Madryn | - | San Martín de Tucumán | 1:2 | ||||
| 4. Round | 05/03/2022 | Defensores de Belgrano | - | Deportivo Madryn | 1:2 |  |
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| 5. Round | 12/03/2022 | Deportivo Madryn | - | Brown de Adrogué | 1:1 | ||||
| 7. Round | 23/03/2022 | Deportivo Madryn | - | Guillermo Brown | 0:1 | ||||
| 9. Round | 03/04/2022 | Deportivo Madryn | - | Ramón Santamarina | 1:1 | ||||
| 11. Round | 16/04/2022 | Deportivo Madryn | - | Atlanta | 4:1 | ||||
| 12. Round | 23/04/2022 | San Martín de San Juan | - | Deportivo Madryn | 3:2 | ||||
| 13. Round | 30/04/2022 | Deportivo Madryn | - | Chaco For Ever | 3:2 |
Argentina