| 1. Round | 11/02/2022 | Unión de Santa Fe II | - | River Plate II | 0:0 | ||||
| 2. Round | 15/02/2022 | River Plate II | - | Patronato de Paraná II | 1:0 |  |
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| 3. Round | 19/02/2022 | Newell's Old Boys II | - | River Plate II | 1:2 | ||||
| 4. Round | 24/02/2022 | River Plate II | - | Racing Club II | 4:2 | |
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| 6. Round | 10/03/2022 | River Plate II | - | Gimnasia de La Plata II | 2:4 | ||||
| 7. Round | 18/03/2022 | River Plate II | - | Boca Juniors II | 0:0 | ||||
| 8. Round | 01/04/2022 | Defensa y Justicia II | - | River Plate II | 2:0 | |
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| 10. Round | 14/04/2022 | Banfield II | - | River Plate II | 2:3 | ||||
| 11. Round | 20/04/2022 | Talleres de Córdoba II | - | River Plate II | 1:1 | ||||
| 12. Round | 25/04/2022 | River Plate II | - | Atlético Tucumán II | 4:0 | |
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| 13. Round | 29/04/2022 | Sarmiento de Junín II | - | River Plate II | 1:2 | ||||
| 14. Round | 05/05/2022 | River Plate II | - | Platense II | 2:2 |
Argentina