| 16. Round | 06/02/2022 | Le Mans FC [Youth B] | - | US Orléans [Youth B] | 3:1 | ||||
| 20. Round | 20/03/2022 | Le Mans FC [Youth B] | - | Havre AC [Youth B] | 0:0 | ||||
| 21. Round | 27/03/2022 | Blois Foot 41 [Youth B] | - | Le Mans FC [Youth B] | 1:4 |  |
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| 22. Round | 03/04/2022 | Le Mans FC [Youth B] | - | Paris Saint-Germain [Youth B] | 1:2 | ||||
| 24. Round | 17/04/2022 | SM Caen [Youth B] | - | Le Mans FC [Youth B] | 2:0 | ||||
| 25. Round | 01/05/2022 | Le Mans FC [Youth B] | - | AS Vitré [Youth B] | 2:0 | ||||
| 26. Round | 15/05/2022 | FC Rouen 1899 [Youth B] | - | Le Mans FC [Youth B] | 3:3 |
France