| 1. Round | 10/02/2022 | Newell's Old Boys II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Round | 15/02/2022 | Defensa y Justicia II | - | Racing Club II | 1:0 | ||||
| 3. Round | 21/02/2022 | San Lorenzo II | - | Defensa y Justicia II | 0:4 | ||||
| 4. Round | 26/02/2022 | Defensa y Justicia II | - | Gimnasia de La Plata II | 2:1 | ||||
| 5. Round | 04/03/2022 | Banfield II | - | Defensa y Justicia II | 2:0 | ||||
| 6. Round | 12/03/2022 | Argentinos Juniors II | - | Defensa y Justicia II | 0:1 | ||||
| 7. Round | 18/03/2022 | Defensa y Justicia II | - | Arsenal de Sarandí II | 3:1 | ||||
| 9. Round | 08/04/2022 | Talleres de Córdoba II | - | Defensa y Justicia II | 1:2 |  |
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| 10. Round | 15/04/2022 | Defensa y Justicia II | - | Atlético Tucumán II | 1:0 | ||||
| 11. Round | 20/04/2022 | Sarmiento de Junín II | - | Defensa y Justicia II | 0:1 |  |
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| 12. Round | 25/04/2022 | Defensa y Justicia II | - | Platense II | 1:1 |
Argentina