| 2. Round | 28/10/2020 | Sportivo Luqueño | - | Defensa y Justicia | 1:2 | ||||
| Round of 16 | 27/11/2020 | Defensa y Justicia | - | Vasco da Gama - RJ | 1:1 | ||||
| Round of 16 | 04/12/2020 | Vasco da Gama - RJ | - | Defensa y Justicia | 0:1 |  |
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| Quarter-finals | 09/12/2020 | Bahia - BA | - | Defensa y Justicia | 2:3 | ||||
| Semi-finals | 12/01/2021 | Coquimbo Unido | - | Defensa y Justicia | 0:0 |
Argentina