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| 1st(1st leg) | Vélez Sarsfield | - | Universidad Católica | 1:2 (0:1) | ||
| 2nd (2nd leg) | Universidad Católica | - | Vélez Sarsfield | 1:3 (0:1) | ||
| 1st(1st leg): 09/12/2020 00:30 | 2nd (2nd leg): 16/12/2020 00:30 | Winner: Vélez Sarsfield | ||||
| 1st(1st leg) | Bahia - BA | - | Defensa y Justicia | 2:3 (1:2) | ||
| 2nd (2nd leg) | Defensa y Justicia | - | Bahia - BA | 1:0 (0:0) | ||
| 1st(1st leg): 09/12/2020 22:15 | 2nd (2nd leg): 16/12/2020 22:15 | Winner: Defensa y Justicia | ||||
| 1st(1st leg) | Atlético Junior | - | Coquimbo Unido | 1:2 (1:0) | ||
| 2nd (2nd leg) | Coquimbo Unido | - | Atlético Junior | 0:1 (0:1) | ||
| 1st(1st leg): 10/12/2020 00:30 | 2nd (2nd leg): 17/12/2020 00:30 | Winner: Coquimbo Unido | ||||
| 1st(1st leg) | Lanús | - | Independiente | 0:0 (0:0) | ||
| 2nd (2nd leg) | Independiente | - | Lanús | 1:3 (0:3) | ||
| 1st(1st leg): 10/12/2020 22:15 | 2nd (2nd leg): 17/12/2020 22:15 | Winner: Lanús | ||||
