| Group D | 08/04/2022 | Ayacucho FC | - | São Paulo FC | 2:3 | ||||
| Group D | 05/05/2022 | Everton | - | São Paulo FC | 0:0 |  |
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| Group D | 20/05/2022 | São Paulo FC | - | Jorge Wilstermann | 3:0 | ||||
| Round of 16 | 01/07/2022 | Universidad Católica | - | São Paulo FC | 2:4 | ||||
| Round of 16 | 08/07/2022 | São Paulo FC | - | Universidad Católica | 4:1 | ||||
| Quarter-finals | 03/08/2022 | São Paulo FC | - | Ceará - CE | 1:0 | ||||
| Quarter-finals | 10/08/2022 | Ceará - CE | - | São Paulo FC | 3:4 pso | ||||
| Semi-finals | 02/09/2022 | Atlético Goianiense | - | São Paulo FC | 3:1 | |
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| Semi-finals | 09/09/2022 | São Paulo FC | - | Atlético Goianiense | 4:2 pso |
Uruguay