| Round of 16 | 01/07/2021 | La Serena | - | Colo-Colo | 1:3 |  |
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| Round of 16 | 05/07/2021 | Colo-Colo | - | La Serena | 4:0 | ||||
| Quarter-finals | 08/07/2021 | Palestino | - | Colo-Colo | 2:3 | ||||
| Quarter-finals | 12/07/2021 | Colo-Colo | - | Palestino | 1:1 | |
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| Semi-finals | 18/08/2021 | Colo-Colo | - | Unión Española | 4:0 | ||||
| Semi-finals | 02/09/2021 | Unión Española | - | Colo-Colo | 2:3 | ||||
| Final | 04/09/2021 | Everton | - | Colo-Colo | 0:2 |
Chile