| Group F | 07/04/2022 | Fortaleza - CE | - | Colo-Colo | 1:2 |  |
|||
| Group F | 13/04/2022 | Colo-Colo | - | Alianza Lima | 2:1 | ||||
| Group F | 28/04/2022 | Colo-Colo | - | River Plate | 1:2 | ||||
| Group F | 06/05/2022 | Alianza Lima | - | Colo-Colo | 1:1 | ||||
| Group F | 20/05/2022 | River Plate | - | Colo-Colo | 4:0 | ||||
| Group F | 25/05/2022 | Colo-Colo | - | Fortaleza - CE | 3:4 | |
Chile