| 4. Round | 18/09/2010 | Karlsruher SC | - | SC Paderborn 07 | 2:1 | ||||
| 6. Round | 24/09/2010 | Karlsruher SC | - | FSV Frankfurt | 0:2 | ||||
| 7. Round | 01/10/2010 | FC Ingolstadt 04 | - | Karlsruher SC | 1:1 | ||||
| 8. Round | 16/10/2010 | Karlsruher SC | - | VfL Bochum | 0:2 |  |
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| 10. Round | 30/10/2010 | Karlsruher SC | - | TSV 1860 München | 2:4 | ||||
| 11. Round | 08/11/2010 | VfL Osnabrück | - | Karlsruher SC | 0:0 | ||||
| 12. Round | 12/11/2010 | Karlsruher SC | - | Erzgebirge Aue | 1:1 | ||||
| 13. Round | 21/11/2010 | FC Augsburg | - | Karlsruher SC | 3:1 | ||||
| 14. Round | 28/11/2010 | Karlsruher SC | - | Rot-Weiß Oberhausen | 4:0 | ||||
| 15. Round | 05/12/2010 | Fortuna Düsseldorf | - | Karlsruher SC | 1:0 | ||||
| 16. Round | 10/12/2010 | Karlsruher SC | - | Arminia Bielefeld | 1:0 | ||||
| 17. Round | 20/12/2010 | 1. FC Union Berlin | - | Karlsruher SC | 3:1 | ||||
| 18. Round | 14/01/2011 | Karlsruher SC | - | SpVgg Greuther Fürth | 1:1 | ||||
| 19. Round | 22/01/2011 | Alemannia Aachen | - | Karlsruher SC | 4:2 |  |
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| 32. Round | 29/04/2011 | Karlsruher SC | - | Fortuna Düsseldorf | 2:2 | ||||
| 34. Round | 15/05/2011 | Karlsruher SC | - | 1. FC Union Berlin | 3:2 |
France