| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 | ||||
| 14. Round | 18/12/2021 | US Colomiers | - | Stade Montois | 1:1 |  |
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| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | ||||
| 27. Round | 30/04/2022 | US Colomiers | - | AS Béziers | 1:3 | ||||
| 30. Round | 28/05/2022 | Le Puy Foot 43 | - | US Colomiers | 2:1 |
France