| 1. Round | 24/07/2021 | CF Pachuca [U18] | - | Club León [U18] | 5:1 | ||||
| 2. Round | 30/07/2021 | Mazatlán FC [U18] | - | CF Pachuca [U18] | 1:1 | ||||
| 3. Round | 09/08/2021 | CF Pachuca [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 4. Round | 14/08/2021 | CF Monterrey [U18] | - | CF Pachuca [U18] | 1:2 | ||||
| 6. Round | 22/08/2021 | Gallos Blancos [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 7. Round | 29/08/2021 | Cruz Azul [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 8. Round | 13/09/2021 | CF Pachuca [U18] | - | Deportivo Toluca [U18] | 2:2 | ||||
| 9. Round | 18/09/2021 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:4 |  |
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| 11. Round | 28/09/2021 | CF Pachuca [U18] | - | CF América [U18] | 4:1 | ||||
| 12. Round | 01/10/2021 | Puebla FC [U18] | - | CF Pachuca [U18] | 0:2 | ||||
| 14. Round | 20/10/2021 | UANL Tigres [U18] | - | CF Pachuca [U18] | 3:2 | ||||
| 16. Round | 30/10/2021 | CF Pachuca [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 5. Round | 03/11/2021 | CF Pachuca [U18] | - | Atlético San Luis [U18] | 3:2 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U18] | - | CF Pachuca [U18] | 2:2 |
Mexico