| 1. Round | 29/08/2021 | UCAM Murcia CF | - | UE Costa Brava | 1:1 | ||||
| 2. Round | 04/09/2021 | UE Costa Brava | - | Atlético Sanluqueño CF | 0:0 | ||||
| 3. Round | 12/09/2021 | FC Barcelona B | - | UE Costa Brava | 0:0 | ||||
| 4. Round | 17/09/2021 | UE Costa Brava | - | UE Cornellà | 1:0 |  |
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| 5. Round | 26/09/2021 | Villarreal CF B | - | UE Costa Brava | 2:0 | ||||
| 6. Round | 03/10/2021 | UE Costa Brava | - | Albacete | 0:3 | ||||
| 7. Round | 10/10/2021 | Algeciras CF | - | UE Costa Brava | 5:1 | ||||
| 8. Round | 17/10/2021 | UE Costa Brava | - | Atlético Baleares | 1:2 | ||||
| 9. Round | 22/10/2021 | UE Costa Brava | - | RB Linense | 0:0 | |
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| 10. Round | 30/10/2021 | Real Betis B | - | UE Costa Brava | 2:0 | ||||
| 11. Round | 06/11/2021 | UE Costa Brava | - | Real Madrid Castilla | 0:1 | ||||
| 13. Round | 20/11/2021 | UE Costa Brava | - | Linares Deportivo | 1:4 | ||||
| 14. Round | 28/11/2021 | Sevilla Atlético | - | UE Costa Brava | 2:1 |
Spain