| 1. Round | 22/08/1965 | RC Strasbourg | - | FC Rouen 1899 | 0:0 | ||||
| 5. Round | 10/09/1965 | RC Strasbourg | - | Red Star FC | 7:1 | ||||
| 6. Round | 18/09/1965 | AS Saint-Étienne | - | RC Strasbourg | 5:1 | ||||
| 7. Round | 25/09/1965 | RC Strasbourg | - | Stade Rennais | 3:1 | ||||
| 8. Round | 29/09/1965 | Nîmes Olympique | - | RC Strasbourg | 4:1 | ||||
| 9. Round | 02/10/1965 | RC Strasbourg | - | FC Sochaux | 5:1 | ||||
| 10. Round | 17/10/1965 | RC Strasbourg | - | Angers SCO | 1:1 | ||||
| 11. Round | 20/10/1965 | AS Monaco | - | RC Strasbourg | 0:0 | ||||
| 12. Round | 24/10/1965 | RC Strasbourg | - | RC Lens | 1:0 | ||||
| 13. Round | 31/10/1965 | AS Cannes | - | RC Strasbourg | 2:1 | ||||
| 14. Round | 11/11/1965 | RC Strasbourg | - | Olympique Lyonnais | 0:0 | ||||
| 15. Round | 14/11/1965 | Stade Français FC | - | RC Strasbourg | 0:2 | ||||
| 16. Round | 21/11/1965 | RC Strasbourg | - | Toulouse FC | 2:2 | ||||
| 17. Round | 28/11/1965 | FC Nantes | - | RC Strasbourg | 2:0 | ||||
| 18. Round | 05/12/1965 | RC Strasbourg | - | Girondins Bordeaux | 3:0 | ||||
| 19. Round | 12/12/1965 | Lille OSC | - | RC Strasbourg | 2:1 | ||||
| 20. Round | 19/12/1965 | FC Rouen 1899 | - | RC Strasbourg | 0:0 |
France