| Group 7 | 21/04/2021 | Vélez Sarsfield | - | Flamengo RJ | 2:3 |  |
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| Group 7 | 27/04/2021 | Flamengo RJ | - | Unión La Calera | 4:1 | |
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| Group 7 | 05/05/2021 | LDU Quito | - | Flamengo RJ | 2:3 | ||||
| Group 7 | 12/05/2021 | Unión La Calera | - | Flamengo RJ | 2:2 |  |
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| Group 7 | 20/05/2021 | Flamengo RJ | - | LDU Quito | 2:2 | ||||
| Group 7 | 28/05/2021 | Flamengo RJ | - | Vélez Sarsfield | 0:0 | ||||
| Round of 16 | 15/07/2021 | Defensa y Justicia | - | Flamengo RJ | 0:1 | ||||
| Round of 16 | 22/07/2021 | Flamengo RJ | - | Defensa y Justicia | 4:1 | |
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| Quarter-finals | 11/08/2021 | Club Olimpia | - | Flamengo RJ | 1:4 | |
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| Quarter-finals | 18/08/2021 | Flamengo RJ | - | Club Olimpia | 5:1 | ||||
| Semi-finals | 30/09/2021 | Barcelona | - | Flamengo RJ | 0:2 | ||||
| Final | 27/11/2021 | Palmeiras | - | Flamengo RJ | 2:1 aet |
Uruguay
Italy