| 5. Round | 02/10/2021 | UD Mutilvera | - | CD Laredo | 1:0 | ||||
| 6. Round | 09/10/2021 | Real Sociedad C | - | UD Mutilvera | 3:1 |  |
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| 9. Round | 30/10/2021 | UD Mutilvera | - | Burgos Promesas | 1:2 | ||||
| 12. Round | 21/11/2021 | Peña Sport FC | - | UD Mutilvera | 2:1 | ||||
| 18. Round | 22/01/2022 | UD Mutilvera | - | UD Logroñés Promesas | 1:0 | ||||
| 19. Round | 30/01/2022 | Náxara CD | - | UD Mutilvera | 4:1 |  |
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| 21. Round | 12/02/2022 | UD Mutilvera | - | CD Tropezón | 2:2 | ||||
| 30. Round | 17/04/2022 | CD Cayón | - | UD Mutilvera | 1:2 |
Spain