| 1. Round | 28/09/1941 | Sevilla FC | - | Real Oviedo | 10:0 | ||||
| 2. Round | 05/10/1941 | Real Oviedo | - | Atlético Aviación | 2:3 |  |
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| 3. Round | 12/10/1941 | Real Oviedo | - | CD Castellón | 4:4 | |
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| 4. Round | 19/10/1941 | Hércules CF | - | Real Oviedo | 4:1 | ||||
| 5. Round | 26/10/1941 | Real Oviedo | - | Espanyol Barcelona | 1:3 | |
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| 6. Round | 02/11/1941 | RC Celta | - | Real Oviedo | 2:1 | ||||
| 7. Round | 09/11/1941 | Real Oviedo | - | Real Madrid | 2:2 | ||||
| 8. Round | 16/11/1941 | Valencia CF | - | Real Oviedo | 5:2 | |
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| 9. Round | 23/11/1941 | Real Oviedo | - | Real Sociedad | 3:1 | |
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| 10. Round | 30/11/1941 | Granada CF | - | Real Oviedo | 8:0 | ||||
| 11. Round | 07/12/1941 | Real Oviedo | - | Athletic Club | 2:1 | |
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| 12. Round | 14/12/1941 | FC Barcelona | - | Real Oviedo | 6:3 | |
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| 13. Round | 21/12/1941 | Real Oviedo | - | Deportivo La Coruña | 1:1 | ||||
| 14. Round | 04/01/1942 | Real Oviedo | - | Sevilla FC | 4:0 | |
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| 16. Round | 18/01/1942 | CD Castellón | - | Real Oviedo | 4:0 | ||||
| 17. Round | 25/01/1942 | Real Oviedo | - | Hércules CF | 2:0 | |
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| 18. Round | 01/02/1942 | Espanyol Barcelona | - | Real Oviedo | 1:1 | ||||
| 20. Round | 15/02/1942 | Real Madrid | - | Real Oviedo | 1:1 | ||||
| 21. Round | 22/02/1942 | Real Oviedo | - | Valencia CF | 1:1 |
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