| 1. Round | 07/08/2021 | EA Guingamp B | - | FC Rouen 1899 | 0:0 | ||||
| 2. Round | 14/08/2021 | AS Vitré | - | EA Guingamp B | 0:4 | ||||
| 4. Round | 28/08/2021 | US Saint-Malo | - | EA Guingamp B | 0:2 | ||||
| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 | ||||
| 6. Round | 11/09/2021 | St-Pryvé St-Hilaire | - | EA Guingamp B | 1:1 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | ||||
| 14. Round | 11/12/2021 | EA Guingamp B | - | US Granvillaise | 1:0 | ||||
| 27. Round | 30/04/2022 | EA Guingamp B | - | Vannes OC | 1:0 |
France