| 14. Round | 11/12/2021 | FC Nantes B | - | AS Béziers | 1:2 | ||||
| 7. Round | 07/01/2022 | FC Nantes B | - | Andrézieux-Bouthéon FC | 1:0 | ||||
| 15. Round | 15/01/2022 | Stade Montois | - | FC Nantes B | 0:4 | ||||
| 16. Round | 22/01/2022 | FC Nantes B | - | Le Puy Foot 43 | 0:0 | ||||
| 19. Round | 18/02/2022 | Montpellier HSC B | - | FC Nantes B | 0:0 | ||||
| 18. Round | 26/02/2022 | FC Nantes B | - | Vendée Les Herbiers | 1:3 | ||||
| 20. Round | 05/03/2022 | FC Nantes B | - | FC Chamalières | 2:1 | ||||
| 21. Round | 11/03/2022 | Andrézieux-Bouthéon FC | - | FC Nantes B | 3:1 | ||||
| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 | ||||
| 23. Round | 02/04/2022 | Bergerac Périgord FC | - | FC Nantes B | 2:0 | ||||
| 24. Round | 09/04/2022 | Canet Roussillon | - | FC Nantes B | 1:0 | ||||
| 26. Round | 23/04/2022 | Trélissac FC | - | FC Nantes B | 1:0 | ||||
| 27. Round | 30/04/2022 | FC Nantes B | - | Moulins Yzeure Foot | 0:1 |
France
Laos