| 1. Round | 22/08/2021 | EA Guingamp [Youth] | - | Le Mans FC [Youth] | 1:3 | ||||
| 2. Round | 29/08/2021 | SA Mérignac [Youth] | - | EA Guingamp [Youth] | 0:3 | ||||
| 3. Round | 05/09/2021 | EA Guingamp [Youth] | - | USSA Vertou [Youth] | 2:0 |  |
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| 4. Round | 12/09/2021 | Girondins Bordeaux [Youth] | - | EA Guingamp [Youth] | 2:1 | ||||
| 5. Round | 19/09/2021 | EA Guingamp [Youth] | - | FC Nantes [Youth] | 0:3 | ||||
| 6. Round | 25/09/2021 | Angers SCO [Youth] | - | EA Guingamp [Youth] | 0:3 | ||||
| 7. Round | 03/10/2021 | EA Guingamp [Youth] | - | LB Châteauroux [Youth] | 2:1 | ||||
| 13. Round | 28/11/2021 | Tours FC [Youth] | - | EA Guingamp [Youth] | 2:2 | |
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| 14. Round | 05/12/2021 | EA Guingamp [Youth] | - | SA Mérignac [Youth] | 5:2 | |
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| 15. Round | 16/01/2022 | USSA Vertou [Youth] | - | EA Guingamp [Youth] | 1:0 | ||||
| 20. Round | 05/02/2022 | FC Nantes [Youth] | - | EA Guingamp [Youth] | 5:0 | ||||
| 21. Round | 13/02/2022 | EA Guingamp [Youth] | - | Angers SCO [Youth] | 0:2 | ||||
| 25. Round | 01/05/2022 | EA Guingamp [Youth] | - | Tours FC [Youth] | 4:0 | |
France