| 10. Round | 23/10/2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 14. Round | 11/12/2021 | EA Guingamp B | - | US Granvillaise | 1:0 | ||||
| 20. Round | 05/03/2022 | EA Guingamp B | - | St-Pryvé St-Hilaire | 1:1 | ||||
| 21. Round | 12/03/2022 | Blois Foot 41 | - | EA Guingamp B | 5:2 | ||||
| 22. Round | 19/03/2022 | EA Guingamp B | - | FC Lorient B | 1:2 | ||||
| 23. Round | 26/03/2022 | SM Caen B | - | EA Guingamp B | 0:2 | ||||
| 28. Round | 14/05/2022 | US Granvillaise | - | EA Guingamp B | 3:4 | ||||
| 29. Round | 21/05/2022 | EA Guingamp B | - | SO Romorantin | 1:2 | ||||
| 30. Round | 28/05/2022 | FC Rouen 1899 | - | EA Guingamp B | 2:1 |
France