| 2. Round | 23/08/2021 | Getafe CF | - | Sevilla FC | 0:1 | ||||
| 3. Round | 29/08/2021 | FC Barcelona | - | Getafe CF | 2:1 | ||||
| 5. Round | 18/09/2021 | Rayo Vallecano | - | Getafe CF | 3:0 | ||||
| 6. Round | 21/09/2021 | Getafe CF | - | Atlético Madrid | 1:2 | ||||
| 7. Round | 26/09/2021 | Real Betis | - | Getafe CF | 2:0 | ||||
| 8. Round | 03/10/2021 | Getafe CF | - | Real Sociedad | 1:1 | ||||
| 9. Round | 16/10/2021 | Levante UD | - | Getafe CF | 0:0 | ||||
| 11. Round | 28/10/2021 | Granada CF | - | Getafe CF | 1:1 | ||||
| 13. Round | 07/11/2021 | Villarreal CF | - | Getafe CF | 1:0 | ||||
| 17. Round | 11/12/2021 | CD Alavés | - | Getafe CF | 1:1 | ||||
| 23. Round | 04/02/2022 | Getafe CF | - | Levante UD | 3:0 | ||||
| 26. Round | 26/02/2022 | Getafe CF | - | CD Alavés | 2:2 | ||||
| 27. Round | 05/03/2022 | Espanyol Barcelona | - | Getafe CF | 2:0 | ||||
| 28. Round | 12/03/2022 | Getafe CF | - | Valencia CF | 0:0 | ||||
| 29. Round | 18/03/2022 | Athletic Club | - | Getafe CF | 1:1 | ||||
| 30. Round | 02/04/2022 | Getafe CF | - | RCD Mallorca | 1:0 | ||||
| 32. Round | 16/04/2022 | Getafe CF | - | Villarreal CF | 1:2 | ||||
| 35. Round | 08/05/2022 | Getafe CF | - | Rayo Vallecano | 0:0 |  |
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| 36. Round | 11/05/2022 | CA Osasuna | - | Getafe CF | 1:1 | ||||
| 38. Round | 22/05/2022 | Elche CF | - | Getafe CF | 3:1 |
Spain