| 10. Round | 29/10/2021 | Real Madrid Castilla | - | Villarreal CF B | 2:1 | ||||
| 11. Round | 07/11/2021 | Villarreal CF B | - | CD Alcoyano | 0:1 | ||||
| 12. Round | 13/11/2021 | Linares Deportivo | - | Villarreal CF B | 2:1 | ||||
| 14. Round | 27/11/2021 | RB Linense | - | Villarreal CF B | 1:2 |  |
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| 23. Round | 13/02/2022 | FC Andorra | - | Villarreal CF B | 0:1 | ||||
| 25. Round | 26/02/2022 | Albacete | - | Villarreal CF B | 1:0 | ||||
| 26. Round | 05/03/2022 | Villarreal CF B | - | CE Sabadell | 0:3 | ||||
| 32. Round | 16/04/2022 | Villarreal CF B | - | Linares Deportivo | 5:0 | |
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| 35. Round | 08/05/2022 | Villarreal CF B | - | Real Madrid Castilla | 4:1 | |
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| 38. Round | 28/05/2022 | Atlético Sanluqueño CF | - | Villarreal CF B | 2:1 |
Spain