| 4. Round | 04/09/2021 | FC Cartagena | - | Real Sociedad B | 1:0 | ||||
| 5. Round | 11/09/2021 | Real Sociedad B | - | SD Eibar | 2:3 | ||||
| 6. Round | 18/09/2021 | Real Zaragoza | - | Real Sociedad B | 1:1 | ||||
| 7. Round | 24/09/2021 | Real Sociedad B | - | SD Huesca | 0:2 | ||||
| 10. Round | 17/10/2021 | Real Sociedad B | - | Real Oviedo | 1:1 |  |
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| 12. Round | 24/10/2021 | SD Amorebieta | - | Real Sociedad B | 1:2 |
Spain