| 4. Round | 17/09/2022 | Racing Ferrol | - | Cultural Leonesa | 3:2 | ||||
| 8. Round | 16/10/2022 | AD Alcorcón | - | Cultural Leonesa | 2:0 | ||||
| 9. Round | 22/10/2022 | Cultural Leonesa | - | Pontevedra CF | 2:0 | ||||
| 11. Round | 06/11/2022 | Cultural Leonesa | - | Rayo Majadahonda | 1:3 | ||||
| 13. Round | 26/11/2022 | Cultural Leonesa | - | Unionistas CF | 2:0 | ||||
| 14. Round | 03/12/2022 | Real Madrid Castilla | - | Cultural Leonesa | 1:1 | ||||
| 16. Round | 10/12/2022 | RC Celta B | - | Cultural Leonesa | 2:1 | ||||
| 17. Round | 18/12/2022 | Cultural Leonesa | - | UD SS Reyes | 4:1 | ||||
| 18. Round | 07/01/2023 | Linares Deportivo | - | Cultural Leonesa | 0:2 | ||||
| 20. Round | 22/01/2023 | AD Ceuta FC | - | Cultural Leonesa | 2:1 |
Spain