| 1. Round | 28/08/2021 | SD Logroñés | - | Real Valladolid B | 1:1 | ||||
| 3. Round | 11/09/2021 | Racing Ferrol | - | Real Valladolid B | 2:1 | ||||
| 4. Round | 18/09/2021 | Real Valladolid B | - | UD SS Reyes | 2:2 | ||||
| 5. Round | 25/09/2021 | Cultural Leonesa | - | Real Valladolid B | 4:2 | ||||
| 12. Round | 14/11/2021 | RC Celta B | - | Real Valladolid B | 3:0 | ||||
| 15. Round | 05/12/2021 | Real Valladolid B | - | Racing Santander | 3:0 | ||||
| 16. Round | 12/12/2021 | Deportivo La Coruña | - | Real Valladolid B | 3:0 | ||||
| 18. Round | 08/01/2022 | CD Badajoz | - | Real Valladolid B | 1:2 | ||||
| 19. Round | 22/01/2022 | Real Valladolid B | - | CD Tudelano | 0:2 | ||||
| 22. Round | 05/02/2022 | Real Valladolid B | - | RC Celta B | 1:3 | ||||
| 24. Round | 20/02/2022 | Real Valladolid B | - | Racing Ferrol | 1:2 | ||||
| 25. Round | 25/02/2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 21. Round | 02/03/2022 | Real Unión | - | Real Valladolid B | 2:1 | ||||
| 26. Round | 06/03/2022 | Real Valladolid B | - | UD Logroñés | 0:2 | ||||
| 27. Round | 06/04/2022 | Real Valladolid B | - | CF Talavera | 2:1 |  |
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| 38. Round | 28/05/2022 | Zamora CF | - | Real Valladolid B | 2:0 |
Ghana