| 4. Round | 28/08/2021 | Montpellier HSC B | - | US Colomiers | 1:2 | ||||
| 14. Round | 18/12/2021 | US Colomiers | - | Stade Montois | 1:1 | ||||
| 21. Round | 12/03/2022 | Bergerac Périgord FC | - | US Colomiers | 1:0 | ||||
| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 |  |
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| 23. Round | 26/03/2022 | US Colomiers | - | Canet Roussillon | 2:3 | |
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| 24. Round | 09/04/2022 | Angoulême CFC | - | US Colomiers | 0:2 | ||||
| 25. Round | 16/04/2022 | US Colomiers | - | Trélissac FC | 1:1 | ||||
| 26. Round | 23/04/2022 | Moulins Yzeure Foot | - | US Colomiers | 3:1 | ||||
| 27. Round | 30/04/2022 | US Colomiers | - | AS Béziers | 1:3 | ||||
| 30. Round | 28/05/2022 | Le Puy Foot 43 | - | US Colomiers | 2:1 |
France