| 1. Round | 07/08/2021 | Andrézieux-Bouthéon FC | - | Angers SCO B | 3:1 | ||||
| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 |  |
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| 11. Round | 06/11/2021 | Le Puy Foot 43 | - | Angers SCO B | 1:0 | ||||
| 12. Round | 20/11/2021 | Bergerac Périgord FC | - | Angers SCO B | 2:1 | |
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| 13. Round | 04/12/2021 | Angers SCO B | - | Vendée Les Herbiers | 2:2 | |
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| 14. Round | 11/12/2021 | Montpellier HSC B | - | Angers SCO B | 0:4 | ||||
| 15. Round | 15/01/2022 | Angers SCO B | - | FC Chamalières | 1:1 | ||||
| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | ||||
| 17. Round | 05/02/2022 | Angers SCO B | - | FC Nantes B | 1:0 | |
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| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO B | 1:1 | ||||
| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | ||||
| 22. Round | 19/03/2022 | AS Béziers | - | Angers SCO B | 1:1 | |
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| 23. Round | 26/03/2022 | Angers SCO B | - | Stade Montois | 0:0 | ||||
| 24. Round | 09/04/2022 | Bourges Foot 18 | - | Angers SCO B | 0:1 |  |
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France
Guinea