2. Round | 30/07/2021 | FK Lviv | - | Shakhtar Donetsk | 0:3 | ||||
4. Round | 13/08/2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
5. Round | 21/08/2021 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 | ||||
6. Round | 29/08/2021 | FC Mynai | - | Shakhtar Donetsk | 1:1 | ||||
7. Round | 11/09/2021 | Shakhtar Donetsk | - | SK Dnipro-1 | 2:0 | ||||
9. Round | 25/09/2021 | Shakhtar Donetsk | - | NK Veres | 4:1 | ||||
11. Round | 15/10/2021 | Shakhtar Donetsk | - | Zorya Lugansk | 6:1 | ||||
12. Round | 23/10/2021 | Vorskla Poltava | - | Shakhtar Donetsk | 0:2 | ||||
13. Round | 30/10/2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 | ||||
14. Round | 07/11/2021 | Kolos Kovalivka | - | Shakhtar Donetsk | 1:3 | ||||
15. Round | 20/11/2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 | ||||
18. Round | 11/12/2021 | FK Oleksandriya | - | Shakhtar Donetsk | 1:2 |