| 19. Round | 30/01/2022 | CS Puertollano CF | - | Atlético Mancha Real | 1:2 | ||||
| 20. Round | 05/02/2022 | Levante UD B | - | CS Puertollano CF | 0:0 | ||||
| 21. Round | 13/02/2022 | CS Puertollano CF | - | CD Toledo | 2:1 |  |
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| 22. Round | 20/02/2022 | CD El Ejido 2012 | - | CS Puertollano CF | 2:0 | ||||
| 23. Round | 27/02/2022 | CS Puertollano CF | - | CD Marchamalo | 1:2 | ||||
| 24. Round | 06/03/2022 | CF La Nucía | - | CS Puertollano CF | 3:2 | ||||
| 25. Round | 13/03/2022 | CS Puertollano CF | - | Recreativo Granada | 3:0 | ||||
| 26. Round | 20/03/2022 | CD Eldense | - | CS Puertollano CF | 3:2 | ||||
| 27. Round | 27/03/2022 | CS Puertollano CF | - | CF Intercity | 0:1 | ||||
| 28. Round | 03/04/2022 | Hércules CF | - | CS Puertollano CF | 2:1 | |
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| 29. Round | 10/04/2022 | CS Puertollano CF | - | Mar Menor CF | 4:0 | |
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| 30. Round | 17/04/2022 | Real Murcia | - | CS Puertollano CF | 3:1 | ||||
| 31. Round | 24/04/2022 | CS Puertollano CF | - | UD Alzira | 1:3 | ||||
| 32. Round | 01/05/2022 | UD Melilla | - | CS Puertollano CF | 2:1 | |
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| 33. Round | 08/05/2022 | UD Socuéllamos | - | CS Puertollano CF | 2:3 | ||||
| 34. Round | 15/05/2022 | CS Puertollano CF | - | Águilas FC | 1:2 |
Spain