| 1. Round | 08/08/2010 | Montpellier HSC | - | Girondins Bordeaux | 1:0 | ||||
| 2. Round | 17/08/2010 | AS Monaco | - | Montpellier HSC | 0:0 |  |
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| 3. Round | 22/08/2010 | Montpellier HSC | - | SM Caen | 0:0 | ||||
| 4. Round | 28/08/2010 | Valenciennes FC | - | Montpellier HSC | 0:1 | ||||
| 19. Round | 21/12/2010 | FC Lorient | - | Montpellier HSC | 0:0 | ||||
| 20. Round | 15/01/2011 | Montpellier HSC | - | Valenciennes FC | 2:1 | |
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| 24. Round | 20/02/2011 | Montpellier HSC | - | Lille OSC | 1:0 | ||||
| 26. Round | 05/03/2011 | Montpellier HSC | - | Stade Rennais | 0:1 | ||||
| 27. Round | 13/03/2011 | Paris Saint-Germain | - | Montpellier HSC | 2:2 | ||||
| 30. Round | 10/04/2011 | Montpellier HSC | - | OGC Nice | 1:1 | ||||
| 34. Round | 07/05/2011 | AJ Auxerre | - | Montpellier HSC | 1:0 | |
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| 35. Round | 11/05/2011 | Montpellier HSC | - | FC Lorient | 3:1 |  |
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| 36. Round | 15/05/2011 | SM Caen | - | Montpellier HSC | 2:0 | ||||
| 37. Round | 21/05/2011 | Montpellier HSC | - | AS Monaco | 0:1 |
France