| 16. Round | 09/01/2022 | Blackburn Rovers U23 | - | Manchester City U23 | 3:5 | ||||
| 17. Round | 17/01/2022 | Tottenham Hotspur U23 | - | Blackburn Rovers U23 | 1:1 | ||||
| 18. Round | 24/01/2022 | Blackburn Rovers U23 | - | Leeds United U23 | 4:0 |  |
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| 19. Round | 04/02/2022 | Blackburn Rovers U23 | - | Brighton & Hove Albion U23 | 6:0 | ||||
| 20. Round | 20/02/2022 | Liverpool FC U23 | - | Blackburn Rovers U23 | 1:1 | ||||
| 25. Round | 25/04/2022 | Blackburn Rovers U23 | - | Crystal Palace U23 | 2:1 |
Ireland