| 1. Round | 07/09/2018 | FC Twente [Women] | - | PSV Eindhoven [Women] | 1:0 | ||||
| 2. Round | 14/09/2018 | PEC Zwolle [Women] | - | FC Twente [Women] | 4:2 | ||||
| 3. Round | 21/09/2018 | FC Twente [Women] | - | AFC Ajax [Women] | 2:2 | ||||
| 4. Round | 28/09/2018 | ADO Den Haag [Women] | - | FC Twente [Women] | 3:1 | ||||
| 5. Round | 12/10/2018 | vv Alkmaar [Women] | - | FC Twente [Women] | 0:5 | ||||
| 6. Round | 19/10/2018 | FC Twente [Women] | - | sc Heerenveen [Women] | 0:0 | ||||
| 7. Round | 26/10/2018 | Excelsior Barendrecht [Women] | - | FC Twente [Women] | 1:3 |  |
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| 12. Round | 30/11/2018 | AFC Ajax [Women] | - | FC Twente [Women] | 1:2 | ||||
| 13. Round | 07/12/2018 | FC Twente [Women] | - | ADO Den Haag [Women] | 5:1 | ||||
| 14. Round | 11/12/2018 | FC Twente [Women] | - | vv Alkmaar [Women] | 4:2 | ||||
| 15. Round | 14/12/2018 | sc Heerenveen [Women] | - | FC Twente [Women] | 0:2 | ||||
| 16. Round | 21/12/2018 | FC Twente [Women] | - | Excelsior Barendrecht [Women] | 6:1 | ||||
| 18. Round | 08/02/2019 | FC Twente [Women] | - | Achilles'29 [Women] | 4:0 | |
Belgium