| 13. Round | 28/11/2021 | CD Tropezón | - | CF Ardoi | 1:1 |  |
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| 14. Round | 05/12/2021 | Peña Sport FC | - | CD Tropezón | 2:1 | ||||
| 15. Round | 12/12/2021 | CD Tropezón | - | CD Cayón | 1:1 | |
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| 16. Round | 19/12/2021 | Rayo Cantabria | - | CD Tropezón | 2:0 | ||||
| 17. Round | 09/01/2022 | CD Tropezón | - | Sestao River | 1:0 | ||||
| 18. Round | 23/01/2022 | CD Tropezón | - | CA Osasuna B | 0:3 | |
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| 19. Round | 30/01/2022 | SD Gernika | - | CD Tropezón | 1:0 | |
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| 20. Round | 06/02/2022 | CD Tropezón | - | UD Logroñés Promesas | 0:0 | ||||
| 21. Round | 12/02/2022 | UD Mutilvera | - | CD Tropezón | 2:2 | |
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| 24. Round | 05/03/2022 | CD Laredo | - | CD Tropezón | 3:1 | ||||
| 25. Round | 13/03/2022 | CD Tropezón | - | Real Sociedad C | 0:1 | ||||
| 26. Round | 19/03/2022 | AD San Juan | - | CD Tropezón | 4:3 | |
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| 27. Round | 27/03/2022 | CD Tropezón | - | Arenas de Getxo | 1:3 | |
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| 28. Round | 02/04/2022 | Burgos Promesas | - | CD Tropezón | 2:3 | |
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| 29. Round | 10/04/2022 | CD Tropezón | - | Racing Rioja CF | 2:1 |  |
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| 31. Round | 24/04/2022 | CD Tropezón | - | Peña Sport FC | 6:1 | ||||
| 32. Round | 01/05/2022 | CD Cayón | - | CD Tropezón | 4:3 | ||||
| 33. Round | 08/05/2022 | CD Tropezón | - | Rayo Cantabria | 0:2 | ||||
| 34. Round | 15/05/2022 | Sestao River | - | CD Tropezón | 4:2 |
Spain