| 4. Round | 26/09/2021 | CD Toledo | - | CS Puertollano CF | 1:4 | ||||
| 6. Round | 10/10/2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ||||
| 8. Round | 24/10/2021 | Recreativo Granada | - | CS Puertollano CF | 2:1 | ||||
| 9. Round | 31/10/2021 | CS Puertollano CF | - | CD Eldense | 0:1 | ||||
| 15. Round | 12/12/2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 17. Round | 09/01/2022 | Águilas FC | - | CS Puertollano CF | 1:0 |  |
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| 20. Round | 05/02/2022 | Levante UD B | - | CS Puertollano CF | 0:0 | ||||
| 25. Round | 13/03/2022 | CS Puertollano CF | - | Recreativo Granada | 3:0 | |
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| 26. Round | 20/03/2022 | CD Eldense | - | CS Puertollano CF | 3:2 |
Spain