| 3. Round | 21/08/2021 | Louhans-Cuiseaux | - | AS Monaco B | 1:1 | ||||
| 4. Round | 28/08/2021 | AS Monaco B | - | Hyères FC | 0:1 | ||||
| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 |  |
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| 6. Round | 11/09/2021 | SC Toulon | - | AS Monaco B | 3:0 | ||||
| 7. Round | 18/09/2021 | AS Monaco B | - | FC Martigues | 2:0 | ||||
| 8. Round | 25/09/2021 | GFA Rumilly Vallières | - | AS Monaco B | 1:2 | ||||
| 11. Round | 06/11/2021 | AS Monaco B | - | GOAL FC | 0:2 | ||||
| 13. Round | 04/12/2021 | AS Monaco B | - | Jura Sud | 1:1 | ||||
| 14. Round | 11/12/2021 | Olympique Marseille B | - | AS Monaco B | 0:1 | ||||
| 15. Round | 15/01/2022 | AS Monaco B | - | Marignane Gignac FC | 0:1 | ||||
| 17. Round | 05/02/2022 | AS Monaco B | - | Louhans-Cuiseaux | 1:1 | ||||
| 18. Round | 12/02/2022 | Hyères FC | - | AS Monaco B | 3:1 | |
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| 24. Round | 09/04/2022 | AS Monaco B | - | Étoile FC | 0:1 | ||||
| 26. Round | 23/04/2022 | AS Monaco B | - | Aubagne FC | 1:1 |  |
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| 30. Round | 28/05/2022 | AS Monaco B | - | Olympique Lyonnais B | 4:1 |
Senegal