| 1. Round | 28/07/2000 | Paris Saint-Germain | - | RC Strasbourg | 3:1 | ||||
| 2. Round | 05/08/2000 | RC Strasbourg | - | Lille OSC | 0:4 | ||||
| 3. Round | 12/08/2000 | RC Strasbourg | - | AS Monaco | 1:3 | ||||
| 4. Round | 19/08/2000 | Stade Rennais | - | RC Strasbourg | 3:0 | ||||
| 5. Round | 26/08/2000 | RC Strasbourg | - | CS Sedan | 3:2 | ||||
| 6. Round | 06/09/2000 | FC Metz | - | RC Strasbourg | 1:0 |  |
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| 10. Round | 30/09/2000 | RC Lens | - | RC Strasbourg | 0:0 |  |
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| 11. Round | 14/10/2000 | RC Strasbourg | - | FC Nantes | 0:5 | ||||
| 13. Round | 28/10/2000 | RC Strasbourg | - | Olympique Marseille | 1:1 | ||||
| 14. Round | 04/11/2000 | Toulouse FC | - | RC Strasbourg | 0:0 | ||||
| 15. Round | 12/11/2000 | RC Strasbourg | - | Girondins Bordeaux | 0:2 | ||||
| 16. Round | 19/11/2000 | AJ Auxerre | - | RC Strasbourg | 1:2 | ||||
| 23. Round | 13/01/2001 | SC Bastia | - | RC Strasbourg | 3:1 | |
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| 24. Round | 27/01/2001 | RC Strasbourg | - | ESTAC Troyes | 3:3 | ||||
| 31. Round | 14/04/2001 | Girondins Bordeaux | - | RC Strasbourg | 2:1 | ||||
| 34. Round | 19/05/2001 | RC Strasbourg | - | Paris Saint-Germain | 1:2 |
France