| 3. Round | 21/08/2021 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
| 4. Round | 28/08/2021 | Olympique Marseille | - | AS Saint-Étienne | 3:1 | ||||
| 5. Round | 12/09/2021 | Montpellier HSC | - | AS Saint-Étienne | 2:0 | ||||
| 6. Round | 18/09/2021 | AS Saint-Étienne | - | Girondins Bordeaux | 1:2 | ||||
| 7. Round | 22/09/2021 | AS Monaco | - | AS Saint-Étienne | 3:1 | ||||
| 8. Round | 25/09/2021 | AS Saint-Étienne | - | OGC Nice | 0:3 | ||||
| 9. Round | 03/10/2021 | AS Saint-Étienne | - | Olympique Lyonnais | 1:1 | ||||
| 10. Round | 17/10/2021 | RC Strasbourg | - | AS Saint-Étienne | 5:1 | ||||
| 11. Round | 22/10/2021 | AS Saint-Étienne | - | Angers SCO | 2:2 | ||||
| 13. Round | 07/11/2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 |  |
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| 14. Round | 21/11/2021 | ESTAC Troyes | - | AS Saint-Étienne | 0:1 | ||||
| 15. Round | 28/11/2021 | AS Saint-Étienne | - | Paris Saint-Germain | 1:3 | ||||
| 16. Round | 01/12/2021 | Stade Brestois 29 | - | AS Saint-Étienne | 1:0 | ||||
| 17. Round | 05/12/2021 | AS Saint-Étienne | - | Stade Rennais | 0:5 | ||||
| 18. Round | 11/12/2021 | Stade de Reims | - | AS Saint-Étienne | 2:0 | ||||
| 22. Round | 21/01/2022 | Olympique Lyonnais | - | AS Saint-Étienne | 1:0 |
Germany
France