| 1. Round | 23/07/1980 | FC Sochaux | - | RC Lens | 1:2 | ||||
| 2. Round | 28/07/1980 | RC Lens | - | Nîmes Olympique | 1:1 | ||||
| 3. Round | 04/08/1980 | Tours FC | - | RC Lens | 1:1 | ||||
| 4. Round | 11/08/1980 | RC Lens | - | OGC Nice | 2:0 | ||||
| 5. Round | 18/08/1980 | Girondins Bordeaux | - | RC Lens | 5:1 | ||||
| 7. Round | 25/08/1980 | Olympique Lyonnais | - | RC Lens | 4:1 | ||||
| 8. Round | 28/08/1980 | RC Lens | - | SC Bastia | 5:0 | ||||
| 9. Round | 08/09/1980 | Lille OSC | - | RC Lens | 2:1 | ||||
| 10. Round | 11/09/1980 | RC Lens | - | RC Strasbourg | 1:2 | ||||
| 11. Round | 22/09/1980 | Angers SCO | - | RC Lens | 1:2 | ||||
| 14. Round | 14/10/1980 | RC Lens | - | AS Monaco | 0:0 | ||||
| 15. Round | 17/10/1980 | FC Metz | - | RC Lens | 0:2 | ||||
| 16. Round | 30/10/1980 | RC Lens | - | AS Saint-Étienne | 1:1 | ||||
| 17. Round | 07/11/1980 | Stade Lavallois | - | RC Lens | 3:0 | ||||
| 31. Round | 06/04/1981 | RC Lens | - | US Valenciennes-Anzin | 1:2 | ||||
| 32. Round | 14/04/1981 | AS Monaco | - | RC Lens | 1:0 | ||||
| 34. Round | 04/05/1981 | AS Saint-Étienne | - | RC Lens | 0:0 | ||||
| 37. Round | 28/05/1981 | RC Lens | - | Paris Saint-Germain | 2:3 |
Réunion