| 1. Round | 12/02/2022 | Banfield | - | San Lorenzo | 0:0 | ||||
| 3. Round | 21/02/2022 | Banfield | - | Gimnasia de La Plata | 4:0 | ||||
| 5. Round | 06/03/2022 | Banfield | - | Defensa y Justicia | 2:3 | ||||
| 7. Round | 19/03/2022 | Lanús | - | Banfield | 0:1 | ||||
| 8. Round | 02/04/2022 | Banfield | - | Argentinos Juniors | 0:2 | ||||
| 9. Round | 10/04/2022 | Patronato de Paraná | - | Banfield | 0:1 |  |
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| 10. Round | 18/04/2022 | Banfield | - | River Plate | 1:2 |  |
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| 11. Round | 20/04/2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 12. Round | 24/04/2022 | Banfield | - | Talleres de Córdoba | 3:1 | ||||
| 13. Round | 30/04/2022 | Racing Club | - | Banfield | 1:1 | ||||
| 14. Round | 10/05/2022 | Banfield | - | Atlético Tucumán | 1:1 |
Argentina