| 4. Round | 19/08/2000 | AS Saint-Étienne | - | Girondins Bordeaux | 1:0 | ||||
| 5. Round | 27/08/2000 | AJ Auxerre | - | AS Saint-Étienne | 4:3 | ||||
| 20. Round | 10/12/2000 | Girondins Bordeaux | - | AS Saint-Étienne | 2:1 |  |
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| 21. Round | 16/12/2000 | AS Saint-Étienne | - | AJ Auxerre | 2:0 | ||||
| 22. Round | 21/12/2000 | Olympique Lyonnais | - | AS Saint-Étienne | 2:1 | ||||
| 23. Round | 13/01/2001 | AS Saint-Étienne | - | Paris Saint-Germain | 1:0 | ||||
| 24. Round | 27/01/2001 | Lille OSC | - | AS Saint-Étienne | 4:1 | ||||
| 25. Round | 03/02/2001 | AS Saint-Étienne | - | RC Strasbourg | 3:3 | ||||
| 26. Round | 06/02/2001 | Stade Rennais | - | AS Saint-Étienne | 3:0 | ||||
| 27. Round | 17/02/2001 | AS Saint-Étienne | - | CS Sedan | 0:2 | ||||
| 29. Round | 17/03/2001 | AS Saint-Étienne | - | SC Bastia | 2:1 | ||||
| 30. Round | 07/04/2001 | ESTAC Troyes | - | AS Saint-Étienne | 0:0 | ||||
| 31. Round | 14/04/2001 | AS Monaco | - | AS Saint-Étienne | 5:3 | ||||
| 32. Round | 28/04/2001 | AS Saint-Étienne | - | RC Lens | 1:1 |
France