| 7. Round | 18/09/2021 | US Colomiers | - | Bergerac Périgord FC | 0:1 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 | ||||
| 9. Round | 09/10/2021 | Canet Roussillon | - | US Colomiers | 1:0 | ||||
| 10. Round | 23/10/2021 | US Colomiers | - | Angoulême CFC | 3:3 | ||||
| 11. Round | 06/11/2021 | Trélissac FC | - | US Colomiers | 0:0 | ||||
| 12. Round | 20/11/2021 | US Colomiers | - | Moulins Yzeure Foot | 0:1 | ||||
| 13. Round | 04/12/2021 | AS Béziers | - | US Colomiers | 3:0 | ||||
| 14. Round | 18/12/2021 | US Colomiers | - | Stade Montois | 1:1 | ||||
| 30. Round | 28/05/2022 | Le Puy Foot 43 | - | US Colomiers | 2:1 |
France