| 2. Round | 04/09/2021 | SO Cholet [Youth B] | - | FC Lorient [Youth B] | 3:3 |  |
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| 3. Round | 11/09/2021 | FC Lorient [Youth B] | - | USSA Vertou [Youth B] | 1:2 | ||||
| 5. Round | 25/09/2021 | Stade brestois 29 [Youth B] | - | FC Lorient [Youth B] | 4:0 | ||||
| 8. Round | 17/10/2021 | FC Lorient [Youth B] | - | La Roche VF [Youth B] | 6:1 | ||||
| 9. Round | 23/10/2021 | CPBB Rennes [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 12. Round | 28/11/2021 | FC Lorient [Youth B] | - | FC Nantes [Youth B] | 1:3 | ||||
| 13. Round | 05/12/2021 | Angers SCO [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 14. Round | 29/01/2022 | FC Lorient [Youth B] | - | SO Cholet [Youth B] | 5:2 | ||||
| 15. Round | 26/02/2022 | USSA Vertou [Youth B] | - | FC Lorient [Youth B] | 1:0 | ||||
| 19. Round | 13/03/2022 | FC Lorient [Youth B] | - | EA Guingamp [Youth B] | 3:4 | ||||
| 21. Round | 26/03/2022 | FC Lorient [Youth B] | - | CPBB Rennes [Youth B] | 4:1 | |
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| 22. Round | 03/04/2022 | Angoulême CFC [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 23. Round | 09/04/2022 | FC Lorient [Youth B] | - | Vannes OC [Youth B] | 4:2 | ||||
| 24. Round | 16/04/2022 | FC Nantes [Youth B] | - | FC Lorient [Youth B] | 5:3 |
France
Guadeloupe