| 1. Round | 08/08/2021 | AS Saint-Étienne | - | FC Lorient | 1:1 | ||||
| 2. Round | 13/08/2021 | FC Lorient | - | AS Monaco | 1:0 | ||||
| 12. Round | 31/10/2021 | RC Strasbourg | - | FC Lorient | 4:0 | ||||
| 13. Round | 07/11/2021 | FC Lorient | - | Stade Brestois 29 | 1:2 | ||||
| 27. Round | 04/03/2022 | FC Lorient | - | Olympique Lyonnais | 1:4 | ||||
| 35. Round | 01/05/2022 | FC Lorient | - | Stade de Reims | 1:2 | ||||
| 36. Round | 08/05/2022 | FC Lorient | - | Olympique Marseille | 0:3 | ||||
| 37. Round | 14/05/2022 | Girondins Bordeaux | - | FC Lorient | 0:0 | ||||
| 38. Round | 21/05/2022 | FC Lorient | - | ESTAC Troyes | 1:1 |
France