| 1. Round | 29/08/2021 | Olympique Lyonnais [Youth B] | - | RC Strasbourg [Youth B] | 4:1 | ||||
| 2. Round | 05/09/2021 | ASPTT Dijon [Youth B] | - | Olympique Lyonnais [Youth B] | 0:5 | ||||
| 3. Round | 12/09/2021 | Olympique Lyonnais [Youth B] | - | FC Bourg-Péronnas [Youth B] | 3:0 | ||||
| 6. Round | 03/10/2021 | FC Metz [Youth B] | - | Olympique Lyonnais [Youth B] | 0:3 | ||||
| 7. Round | 10/10/2021 | Olympique Lyonnais [Youth B] | - | FC Lyon [Youth B] | 2:2 | ||||
| 8. Round | 17/10/2021 | Olympique Lyonnais [Youth B] | - | FC Sochaux [Youth B] | 4:0 | ||||
| 9. Round | 24/10/2021 | FC Annecy [Youth B] | - | Olympique Lyonnais [Youth B] | 2:1 | ||||
| 10. Round | 14/11/2021 | Olympique Lyonnais [Youth B] | - | Dijon FCO [Youth B] | 5:0 | ||||
| 11. Round | 21/11/2021 | FC Mulhouse [Youth B] | - | Olympique Lyonnais [Youth B] | 2:4 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 13. Round | 05/12/2021 | AS Nancy Lorraine [Youth B] | - | Olympique Lyonnais [Youth B] | 0:1 | ||||
| 26. Round | 15/05/2022 | RC Strasbourg [Youth B] | - | Olympique Lyonnais [Youth B] | 1:3 |
France