| 1. Round | 07/08/2021 | Trélissac FC | - | Moulins Yzeure Foot | 0:2 | ||||
| 2. Round | 14/08/2021 | AS Béziers | - | Trélissac FC | 2:0 | ||||
| 3. Round | 21/08/2021 | Trélissac FC | - | Stade Montois | 3:1 |  |
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| 4. Round | 28/08/2021 | Bourges Foot 18 | - | Trélissac FC | 2:0 | ||||
| 5. Round | 04/09/2021 | Trélissac FC | - | Le Puy Foot 43 | 0:1 | ||||
| 15. Round | 14/01/2022 | Bergerac Périgord FC | - | Trélissac FC | 0:0 | ||||
| 17. Round | 05/02/2022 | Stade Montois | - | Trélissac FC | 0:3 | ||||
| 18. Round | 12/02/2022 | Trélissac FC | - | Bourges Foot 18 | 1:2 | ||||
| 16. Round | 23/02/2022 | Trélissac FC | - | AS Béziers | 0:0 | ||||
| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO II | 1:1 | ||||
| 21. Round | 12/03/2022 | Vendée Les Herbiers | - | Trélissac FC | 2:0 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC (CFA) | 3:0 | ||||
| 23. Round | 26/03/2022 | FC Chamalières | - | Trélissac FC | 2:1 | ||||
| 24. Round | 09/04/2022 | Trélissac FC | - | Andrézieux-Bouthéon FC | 0:1 | ||||
| 27. Round | 30/04/2022 | Canet Roussillon | - | Trélissac FC | 1:2 |
France